Heart & Vascular Diseases

Heart Attacks

Myocardial infarctions (aka heart attacks) happen when the blood flow to the heart decreases or stops, causing damage to heart muscle. Most common symptoms of heart attacks include chest pain or discomfort that travels into the arm, shoulder, back, neck and jaw.

Driven by new findings that myocardium (heart tissue) can regenerate stem cells have emerged as a promising therapeutic approach for treating heart attacks. Studies have explored the use of stem cells from multiple sources (umbilical cord, adult bone marrow, induced pluripotent cells) for tackling heart attacks, the leading cause of death worldwide.

TRIAL HYPOTHESIS CLINICAL TRIAL ID
Assessing the use of umbilical cord stroma-derived multipotent cells to treat myocardial infarction. NCT02323477 Ankara University, Turkey
Comparing early vs late administration of bone marrow-derived stem cells to treat acute myocardial infarctions with reopened infarct-related artery. NCT00384982 Medical University of Vienna, Austria
Looking at the safety and effectiveness of umbilical cord Wharton’s jelly-derived mesenchymal stem cell transfer in people with acute myocardial infarctions. NCT01291329 Navy General Hospital, Beijing
Can autologous bone marrow-derived stem cell infusion improve cardiac function following a myocardial infarction? NCT00275977 Odense University Hospital, Denmark
Comparing the efficiency of unselected bone marrow-derived stem cells and sorted subpopulations of stem cells for treating patients with acute myocardial infarction. NCT00316381 Silesian School of Medicine, Poland
SWiss multicenter intracoronary stem cells study in acute myocardial infarction. NCT00355186 University of Zurich, Switzerland
Is it safe to treat patients with large myocardial infarctions using intracoronary injection of autologous bone marrow-derived mononuclear cells? NCT00389545 Charles University, Czech Republic
Can expanded and cryopreserved allogeneic umbilical cord Wharton’s jelly-derived adult mesenchymal stem cells be used to colonize the pericardial matrix after a heart attack? NCT03798353 Fundació Institut Germans Trias i Pujol, Spain
Injection of stem cells at time of coronary artery bypass grafting. NCT01033617 Centre hospitalier de l’Université de Montréal
Using adult stem cells 2 to 3 weeks after a heart attack to improve heart function in people who have had a procedure called a percutaneous coronary intervention. NCT00684060 The University of Texas Health Science Center, Houston
Studying the safety and efficacy of intramyocardial injection of autologous mesenchymal stem cells in patients undergoing cardiac surgery for coronary artery bypass grafting. NCT00587990 University of Miami